Design and Antileishmanial Activity of Amphotericin B-Loaded Stable Ionic Amphiphile Biovector Formulations-Reference-Cited by-同舟云学术

Design and Antileishmanial Activity of Amphotericin B-Loaded Stable Ionic Amphiphile Biovector Formulations

Published:2002-05 Issue:5 Volume:46 Page:1597-1601
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Loiseau P. M.¹,Imbertie L.²,Bories C.¹,Betbeder D.²,De Miguel I.²

Affiliation:

1. LBCOP, UPRES 398-IFR 75, Faculté de Pharmacie, Université de Paris XI, 92290 Chatenay-Malabry Cedex

2. Biovector Therapeutics S. A., Chemin du Chêne Vert, 31676 Labège Cedex, France

Abstract

ABSTRACT A new delivery system, Ionic Amphiphilic Biovector (ABV), comprised of anionic lipids (dipalmitoyl phosphatidyl glycerol) included in a cationic cross-linked polysaccharide matrix was used as a reservoir for amphotericin B (AmB). Two ABV formulations exhibited an in vitro and in vivo efficacy similar to commercial AmBisome against Leishmania donovani -infected mice. The higher stability of these ABV formulations indicates their potential for further development and applications.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.5.1597-1601.2002

Reference6 articles.

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3. Davidson, R. N., S. L. Croft, A. Scott, M. Maini, A. H. Moody, and A. D. M. Bryceson. 1991. Liposomal amphotericin B in drug-resistant visceral leishmaniasis. Lancet337:1061-1062.

4. In Vitro Reversion of Amphotericin B Resistance in Leishmania donovani by Poloxamer 188

5. Imbertie, I., D. Betbeder, F. Lescure, P. Von Hoegen, I. De Miguel. 2001. New Ionic Amphiphile BiovectorTM as carrier of poor solubility drugs. J. Control Release72:249-252.

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