Affiliation:
1. Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721
Abstract
ABSTRACT
Tetracycline resistance is common among isolates of the animal commensal and opportunistic pathogen
Arcanobacterium pyogenes
. The tetracycline resistance determinant cloned from two bovine isolates of
A. pyogenes
was highly similar at the DNA level (92% identity) to the
tet
(W) gene, encoding a ribosomal protection tetracycline resistance protein, from the rumen bacterium
Butyrivibrio fibrisolvens
. The
tet
(W) gene was found in all 20 tetracycline-resistant isolates tested, indicating that it is a widely distributed determinant of tetracycline resistance in this organism. In 25% of tetracycline-resistant isolates, the
tet
(W) gene was associated with a
mob
gene, encoding a functional mobilization protein, and an origin of transfer, suggesting that the determinant may be transferable to other bacteria. In fact, low-frequency transfer of
tet
(W) was detected from
mob
+
A. pyogenes
isolates to a tetracycline-sensitive
A. pyogenes
recipient. The mobile nature of this determinant and the presence of
A. pyogenes
in the gastrointestinal tract of cattle and pigs suggest that
A. pyogenes
may have inherited this determinant within the gastrointestinal tracts of these animals.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
59 articles.
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