Affiliation:
1. Laboratoire Glaxo SmithKline, Marly-le-Roi
2. Bicêtre Hospital, Paris, France
Abstract
ABSTRACT
In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (
C
max
) compared to administration with water (7.11 versus 9.10 μg/ml), slightly increased the time to
C
max
(1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h (AUC
0-12
), the AUC
0-∞
, or the concentration at 12 h. Therefore, grapefruit juice does not clinically significantly affect amprenavir pharmacokinetics.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference6 articles.
1. Bailey, D., J. Malcolm, O. Arnold, and D. Spence. 1998. Grapefruit juice-drug interactions. Br. J. Clin. Pharmacol.46:101-110.
2. Jayewardene, A., F. Zhu, F. Awweka, and J. Gambertoglio. 2001. Simple high performance liquid chromatography determination of the protease inhibitor indinavir in human plasma. J. Chromatogr.707:203-211.
3. Koch, G. 1972. The use of nonparametric methods in the statistical analysis of the two period change-over design. Biometrics28:577-588.
4. Kupferschmidt, H., K. Fattinger, H. Reim Ha, F. Follath, and S. Krahenbuhl. 1998. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br. J. Clin. Pharmacol.45:355-359.
5. In Vivo Effect of α
1
-Acid Glycoprotein on Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Protease Inhibitor
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献