Affiliation:
1. Department of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
Abstract
ABSTRACT
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on
Plasmodium falciparum
growth. (6
R
)-6-Fluoro-shikimate and (6
S
)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10
−5
and 2.7 × 10
−4
M, respectively), whereas 2-fluoro-shikimate had no effect.
para
-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
74 articles.
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