Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones-Reference-Cited by-同舟云学术

Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones

Published:1999-10 Issue:10 Volume:43 Page:2513-2516
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brisse Sylvain¹,Fluit Ad C.¹,Wagner Ulrich²,Heisig Peter³,Milatovic Dana¹,Verhoef Jan¹,Scheuring Sybille²,Köhrer Karl²,Schmitz Franz-Josef¹²

Affiliation:

1. Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and

2. Institute for Medical Microbiology and Virology, University Hospital Düsseldorf, D-40225 Düsseldorf,2 and

3. Institute for Pharmaceutical Microbiology, University of Bonn, Bonn,3 Germany

Abstract

ABSTRACT The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.10.2513

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