Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing-Reference-Cited by-同舟云学术

Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

Published:1999-10 Issue:10 Volume:43 Page:2559-2561
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lipman J.¹²,Wallis S. C.¹,Rickard C.²

Affiliation:

1. Division of Anaesthesiology and Intensive Care, University of Queensland,1 and

2. Intensive Care Facility, Royal Brisbane Hospital,2 Brisbane, Queensland, Australia

Abstract

ABSTRACT The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa . Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.10.2559

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