Affiliation:
1. The R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404,1 and
2. the UCLA School of Medicine, Los Angeles, California 900242
Abstract
ABSTRACT
The activities of gemifloxacin (SB 265805, LB20304) and comparator agents were determined by an agar dilution method against 419 clinical strains of less-commonly identified species of anaerobes. Gemifloxacin was generally more active than trovafloxacin against gram-positive strains by one to two dilutions. Peptostreptococci (
Peptostreptococcus asaccharolyticus
,
Peptostreptococcus magnus
,
Peptostreptococcus micros
, and
Peptostreptococcus prevotii
) and
Porphyromonas
spp. (
Porphyromonas asaccharolytica
,
Porphyromonas canoris
,
Porphyromonas gingivalis
, and
Porphyromonas macacae
) were all susceptible to ≤0.25 μg of gemifloxacin per ml. The MICs of gemifloxacin at which 90% of the following strains were inhibited (MIC
90
s) were ≤2 μg/ml:
Actinomyces israelii
,
Actinomyces odontolyticus
,
Clostridium innocuum
,
Clostridium clostridioforme
,
Anaerobiospirillum
spp.,
Bacteroides tectum
,
Bacteroides ureolyticus
,
Bacteroides gracilis
(now
Campylobacter gracilis
),
Prevotella intermedia
,
Prevotella heparinolytica
, and the
Prevotella oris-buccae
group.
Fusobacterium naviforme
and
Fusobacterium necrophorum
were also susceptible to ≤2 μg of gemifloxacin per ml, while
Fusobacterium varium
strains exhibited a bimodal pattern; the other
Fusobacterium
species, such as
Fusobacterium ulcerans
and
Fusobacterium russii
, as well as
Veillonella
spp., the
Prevotella melaninogenica
group,
Prevotella bivia
,
Clostridium difficile
, and
Bilophila wadsworthia
were relatively resistant to gemifloxacin (MIC
90
s, ≥4 μg/ml).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
31 articles.
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