Prevalence of Antimicrobial Resistance in Respiratory Tract Isolates of Streptococcus pneumoniae : Results of a Canadian National Surveillance Study

Author:

Zhanel George G.1234,Karlowsky James A.124,Palatnick Lorraine3,Vercaigne Laverne2,Low Donald E.5,Hoban Daryl J.14,

Affiliation:

1. Department of Medical Microbiology, Faculty of Medicine,1 and

2. Faculty of Pharmacy,2 University of Manitoba, and

3. Departments of Medicine3 and

4. Clinical Microbiology,4 Health Sciences Centre, Winnipeg, Manitoba, and

5. Department of Microbiology, Mt. Sinai Hospital, Toronto, Ontario,5 Canada

Abstract

ABSTRACT From October 1997 to November 1998, 1,180 respiratory tract isolates of Streptococcus pneumoniae were collected from 18 medical centers in 9 of the 10 Canadian provinces. Penicillin-intermediate and -resistant isolates occurred at rates of 14.8 and 6.4%, respectively, and these rates varied considerably by geographic region. Trimethoprim-sulfamethoxazole, tetracycline, and macrolide rates of nonsusceptibility were 12.2, 10.6, and 8.0 to 9.3%, respectively. The most potent agents studied were newer fluoroquinolones.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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