Treatment of Experimental Staphylococcal Endocarditis Due to a Strain with Reduced Susceptibility In Vitro to Vancomycin: Efficacy of Ampicillin-Sulbactam-Reference-Cited by-同舟云学术

Treatment of Experimental Staphylococcal Endocarditis Due to a Strain with Reduced Susceptibility In Vitro to Vancomycin: Efficacy of Ampicillin-Sulbactam

Published:1999-10 Issue:10 Volume:43 Page:2565-2568
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Backo Mirjana¹,Gaenger Eliza¹,Burkart Anna¹,Chai Yin Li¹,Bayer Arnold S.¹²

Affiliation:

1. Division of Adult Infectious Diseases and St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California 90509,1 and

2. UCLA School of Medicine, Los Angeles, California 900242

Abstract

ABSTRACT We evaluated several 3-day antimicrobial regimens in the treatment of experimental endocarditis caused by an oxacillin-resistant Staphylococcus aureus strain exhibiting intermediate susceptibility in vitro to vancomycin (VISA). Neither vancomycin alone nor trovafloxacin exhibited in vivo efficacy; addition of amikacin to vancomycin yielded a modest in vivo effect. In contrast, the combination of ampicillin and sulbactam was highly effective in vivo, causing a mean decrease in VISA vegetation densities of >5 log 10 CFU/g versus those of untreated controls.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.10.2565

Reference22 articles.

1. Differential antimicrobial pharmacokinetics and pharmacodynamics in right-sided versus left-sided vegetations in experimental Pseudomonas aeruginosa endocarditis.;Bayer A. S.;J. Infect. Dis.,1988

2. Efficacy of vancomycin plus rifampin in experimental aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus: in vitro-in vivo correlations.;Bayer A. S.;J. Infect. Dis.,1985

3. Efficacy of Trovafloxacin, a New Quinolone Antibiotic, in Experimental Staphylococcal Endocarditis Due to Oxacillin-Resistant Strains

4. Valve-site specific pathogenetic differences between right-sided and left-sided bacterial endocarditis.;Bayer A. S.;Chest,1990

5. Pathogenic effects of neutropenia, monocytopenia and steroid treatment in experimental Pseudomonas endocarditis.;Bayer A. S.;Chemotherapy,1989

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of an Amplicon Nanopore Sequencing Strategy for Detection of Mutations Conferring Intermediate Resistance to Vancomycin in Staphylococcus aureus Strains;Microbiology Spectrum;2023-02-14

2. Development of an amplicon nanopore sequencing strategy for detection of mutations conferring intermediate resistance to vancomycin in Staphylococcus aureus strains;2022-07-31

3. Current Paradigms of Combination Therapy in Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: Does it Work, Which Combination, and For Which Patients?;Clinical Infectious Diseases;2021-05-16

4. Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis;Scientific Reports;2020-07-29

5. Consensus Report on Diagnosis, Treatment and Prevention of Infective Endocarditis by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Clinical Microbiology and Infectious Diseases (KLIMIK), Turkish Society of Cardiology (TSC), Turkish Society of Nuclear Medicine (TSNM), Turkish Society of Radiology (TSR), Turkish Dental Association (TDA) and Federation of Turkish Pathology Societies (TURKPATH) Cardiovascular System Study Group;The Turkish Journal of Thoracic and Cardiovascular Surgery;2020-02-17