Potentiation of Artemisinin Activity against Chloroquine-Resistant Plasmodium falciparum Strains by Using Heme Models-Reference-Cited by-同舟云学术

Potentiation of Artemisinin Activity against Chloroquine-Resistant Plasmodium falciparum Strains by Using Heme Models

Published:1999-10 Issue:10 Volume:43 Page:2555-2558
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Benoit-Vical Françoise¹,Robert Anne²,Meunier Bernard²

Affiliation:

1. Laboratoire d’Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, 34060 Montpellier Cedex 2,1 and

2. Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse Cedex 4,2France

Abstract

ABSTRACT The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso -tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.10.2555

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