Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae

Published:1999-01 Issue:1 Volume:43 Page:187-189
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gill Martin J.¹²,Brenwald Nigel P.²,Wise Richard²

Affiliation:

1. Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT,1 and

2. Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH,2United Kingdom

Abstract

ABSTRACT An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.1.187

Reference13 articles.

1. Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae

2. The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin.;Brenwald N. P.;J. Antimicrob. Chemother,1997

3. Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae

4. Construction and evaluation of new drug-resistance cassettes for gene disruption mutagenesis in Streptococcus pneumoniae, using an ami test platform.;Claverys J.-P.;Gene,1995

5. Multiple sequence alignment with hierarchical clustering.;Corpet F.;Nucleic Acids Res.,1988

Cited by 230 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Comprehensive Review of Molecular Mechanisms Leading to the Emergence of Multidrug Resistance in Bacteria;Indian Journal of Microbiology;2024-09-10

2. Effect of erythromycin residuals in food on the development of resistance in Streptococcus pneumoniae: an in vivo study in Galleria mellonella;PeerJ;2024-05-28

3. Combating multidrug-resistance in S. pneumoniae: a G-quadruplex binding inhibitor of efflux pump and its bio-orthogonal assembly;NAR Molecular Medicine;2024-04-01

4. Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis;Antimicrobial Agents and Chemotherapy;2024-03-06

5. Invasive Streptococcus suis isolated in Spain contain a highly promiscuous and dynamic resistome;Frontiers in Cellular and Infection Microbiology;2024-01-22