In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp

Author:

Kenny D. J.1,Russell P.1,Rogers D.1,Eley S. M.1,Titball R. W.1

Affiliation:

1. CBD Porton Down, Salisbury, Wilts SP4 OJQ, United Kingdom

Abstract

ABSTRACT The in vitro antimicrobial susceptibilities of isolates of Burkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities of Burkholderia pseudomallei and Burkholderia cepacia . The antibiotic susceptibility profile of B. mallei resembled that of B. pseudomallei more closely than that of B. cepacia , which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against both B. mallei and B. pseudomallei . Gentamicin was active against B. mallei but not against B. pseudomallei . Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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