Nitric oxide production does not directly increase macrophage candidacidal activity

Author:

Vazquez-Torres A1,Jones-Carson J1,Balish E1

Affiliation:

1. Department of Surgery, University of Wisconsin Medical School, Madison 53706-1532.

Abstract

Some activated murine macrophages produced nitrite but were unable to kill Candida albicans. Furthermore, a nitric oxide (NO) generator inhibited C. albicans growth but was not candidacidal. Our results suggest that NO is candidastatic and that No is not directly involved but is associated with or induces other macrophage candidacidal mechanisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference15 articles.

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2. Acquired immunity to systemic candidiasis in immunodeficient mice;Cantorna M. T.;J. Infect. Dis.,1991

3. Mucosal and systemic candidiasis in congenitally immunodeficient mice;Cantorna M. T.;Infect. Immun.,1990

4. Interleukin-4 and interleukin-10 inhibit nitric oxidedependent macrophage killing of Candida albicans;Cenci E.;Eur. J. Immunol.,1993

5. Characterization of IL-2 receptor expression and function on murine macrophages;Cox G. W.;J. Immunol.,1990

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