Helicobacter-associated gastritis in SCID mice-Reference-Cited by-同舟云学术

Helicobacter-associated gastritis in SCID mice

Published:1995-03 Issue:3 Volume:63 Page:1113-1115
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Blanchard T G¹,Czinn S J¹,Nedrud J G¹,Redline R W¹

Affiliation:

1. Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.

Abstract

Immunodeficient (SCID) and immunocompetent mice were infected with Helicobacter felis to address the role of autoimmunity in Helicobacter-associated gastritis. The extents of inflammation were equivalent in the two groups. The numbers of H. felis organisms were marginally increased in the SCID mice but did not achieve statistical significance. These results indicate that autoimmunity is not necessary to induce disease and that the presence of an adaptive immune system does not significantly affect H. felis colonization.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.63.3.1113-1115.1995

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