The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection-Reference-Cited by-同舟云学术

The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection

Published:2022-01-25 Issue:1 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Eribo Osagie A.¹^ORCID,du Plessis Nelita¹^ORCID,Chegou Novel N.¹^ORCID

Affiliation:

1. DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Abstract

The gut microbiota has emerged as a critical player in host health. Bacteroides fragilis is a prominent member of the gut microbiota within the phyla Bacteroidetes. This commensal bacterium produces unique capsular polysaccharides processed by antigen-presenting cells and activates CD4 + T cells to secrete inflammatory cytokines.

Funder

National Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00321-21

Reference100 articles.

1. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

2. Role of the Microbiota in Immunity and Inflammation

3. Bridging intestinal immunity and gut microbiota by metabolites