TGF-β/IFN-γ Antagonism in Subversion and Self-Defense of Phase II Coxiella burnetii <i>-</i> Infected Dendritic Cells-Reference-Cited by-同舟云学术

TGF-β/IFN-γ Antagonism in Subversion and Self-Defense of Phase II Coxiella burnetii - Infected Dendritic Cells

Published:2023-02-16 Issue:2 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Matthiesen Svea¹,Christiansen Bahne¹²,Jahnke Rico¹,Zaeck Luca M.²,Karger Axel²^ORCID,Finke Stefan²,Franzke Kati³,Knittler Michael R.¹^ORCID

Affiliation:

1. Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Isle of Riems, Germany

2. Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Isle of Riems, Germany

3. Institute of Infectology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Isle of Riems, Germany

Abstract

Dendritic cells (DCs) belong to the first line of innate defense and come into early contact with invading pathogens, including the zoonotic bacterium Coxiella burnetii , the causative agent of Q fever. However, the pathogen-host cell interactions in C. burnetii -infected DCs, particularly the role of mechanisms of immune subversion beyond virulent phase I lipopolysaccharide (LPS), as well as the contribution of cellular self-defense strategies, are not understood.

Funder

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00323-22

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