Complete Sequences of mcr-1 -Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae-Reference-Cited by-同舟云学术

Complete Sequences of mcr-1 -Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae

Published:2016-07 Issue:7 Volume:60 Page:4351-4354
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Li Aiqing¹,Yang Yong¹,Miao Minhui¹,Chavda Kalyan D.²,Mediavilla José R.²,Xie Xiaofang¹,Feng Ping¹,Tang Yi-Wei³^ORCID,Kreiswirth Barry N.²,Chen Liang²,Du Hong¹

Affiliation:

1. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

2. Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

3. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Abstract

ABSTRACT Here we completely sequenced four mcr-1 -haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1 -harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1 -carrying plasmids.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00550-16

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