Regulation of the ammonia assimilatory enzymes in Salmonella typhimurium

Author:

Brenchley J E,Baker C A,Patil L G

Abstract

The regulation of glutamate dehydrogenase (EC 1.4.1.4), glutamine synthetase (EC 6.3.1.2), and glutamate synthase (EC 2.6.1.53) was examined for cultures of Salmonella typhimurium grown with various nitrogen and amino acid sources. In contrast to the regulatory pattern observed in Klebsiella aerogenes, the glutamate dehydrogenase levels of S. typhimurium do not decrease when glutamine synthetase is derepressed during growth with limiting ammonia. Thus, it appears that the S. typhimurium glutamine synthetase does not regulate the synthesis of glutamate dehydrogenase as reported for K. aerogenes. The glutamate dehydrogenase activity does increase, however, during growth of a glutamate auxotroph with glutamate as a limiting amino acid source. The regulation of glutamate synthase levels is complex with the enzyme activity decreasing during growth with glutamate as a nitrogen source, and during growth of auxotrophs with either glutamine or glutamate as limiting amino acids.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference26 articles.

1. Effect of methionine sulfoximine and methionine sulfone on glutamate synthesis in Klebsiella aerogenes;Brenchley J.;J. Bacteriol.,1973

2. Mutants of Klebsiella aerogenes lacking glutamate dehydrogenase;Brenchley J.;J. Bacteriol.,1974

3. Regulation of the synthesis of enzymes responsible for glutamate formation in Klebsiella aerogenes;Brenchley J.;J. Biol. Chem.,1973

4. Studies on the repression of ,8-galactosidase in Escherichia coli;Clark J.;Biochim. Biophys. Acta,1964

5. Identification of the structural gene for glutamine synthetase in Klebsiella aerogenes;DeLeo A.;J. Bacteriol.,1975

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3