Characterization of the Type 8 Capsular Gene Cluster of Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Characterization of the Type 8 Capsular Gene Cluster of Streptococcus pneumoniae

Published:1999-10 Issue:19 Volume:181 Page:6214-6219
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Muñoz Rosario¹²,Mollerach Marta¹³,López Rubens¹,García Ernesto¹

Affiliation:

1. Centro de Investigaciones Biológicas, CSIC,1 and

2. Pharma Mar,2 Madrid, Spain, and

3. Facultad de Farmacia y Bioquı́mica, Universidad de Buenos Aires, Buenos Aires, Argentina3

Abstract

ABSTRACT The complete nucleotide sequence of the capsular gene cluster ( cap8 ) responsible for the biosynthesis of the capsular polysaccharide of Streptococcus pneumoniae type 8 has been determined. The cap8 gene cluster, located between the genes dexB and aliA , is composed of 12 open reading frames. A 14.7-kb DNA fragment embracing the cap8 genes was sufficient to transform an unencapsulated type 3 S. pneumoniae strain to a strain with the type 8 capsule. A possible scenario for the evolution of pneumococcal types 2 and 8 is outlined.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.181.19.6214-6219.1999

Reference45 articles.

1. Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines

2. Molecular and functional analysis of genes required for expression of group IB K antigens in Escherichia coli: characterization of the his-region containing gene clusters for multiple cell-surface polysaccharides;Amor P. A.;Mol. Microbiol.,1997

3. Demonstration of UDP-glucose dehydrogenase activity in cell extracts of Escherichia coli expressing the pneumococcal cap3A gene required for the synthesis of type 3 capsular polysaccharide

4. Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3;Arrecubieta C.;Gene,1995

5. Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Streptococcus pneumoniaeCapsular Polysaccharide;Gram-Positive Pathogens;2019-11-26

2. Streptococcus pneumoniae Capsular Polysaccharide;Microbiology Spectrum;2019-04-12

3. Pneumococcal Capsules and Their Types: Past, Present, and Future;Clinical Microbiology Reviews;2015-07

4. Emerging, Non-PCV13 Serotypes 11A and 35B of Streptococcus pneumoniae Show High Potential for Biofilm Formation In Vitro;PLOS ONE;2015-04-30

5. Population-Based Analysis of Invasive Nontypeable Pneumococci Reveals That Most Have Defective Capsule Synthesis Genes;PLoS ONE;2014-05-15