Evaluation of the Clinical Performance of the cobas 4800 HPV Test in Patients Referred for Colposcopy-Reference-Cited by-同舟云学术

Evaluation of the Clinical Performance of the cobas 4800 HPV Test in Patients Referred for Colposcopy

Published:2013-10 Issue:10 Volume:51 Page:3415-3417
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

White Christine¹²,Keegan Helen¹²,Pilkington Loretto²,Ruttle Carmel²,Kerr Patrick²,Sharp Linda³,O'Toole Sharon¹,Turner Michael⁴,Prendiville Walter⁴,D'Arcy Tom⁴,Fitzpatrick Myra⁵,Lenehan Peter⁵,Flannelly Grainne⁵,O'Leary John J.¹²,Martin Cara M.¹²

Affiliation:

1. Department of Histopathology, Trinity College Dublin, Dublin, Ireland

2. Department of Pathology, Coombe Women's and Infants University Hospital, Dublin, Ireland

3. National Cancer Registry Ireland, Cork, Ireland

4. Department of Obstetrics and Gynaecology, Coombe Women and Infants University Hospital, Dublin, Ireland

5. Department of Obstetrics and Gynaecology, National Maternity Hospital, Dublin, Ireland

Abstract

ABSTRACT The clinical performance of the cobas human papillomavirus (HPV) test for detection of high-grade disease in a colposcopy-referred population was compared with that of Hybrid Capture 2 (HC2). The overall agreement between the tests was 92.3%. Clinical sensitivity and specificity for detection of cervical intraepithelial neoplasia grade 2 or greater (CIN2+) were 90.0% and 55.5% for cobas and 90.5% and 50.2% for HC2, respectively. In conclusion, both tests showed comparable performance for detection of CIN2+.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01949-13

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