C-Reactive Protein Testing for Active Tuberculosis among Inpatients without HIV in Uganda: a Diagnostic Accuracy Study

Author:

Meyer Amanda J.12,Ochom Emmanuel2,Turimumahoro Patricia2,Byanyima Patrick3,Sanyu Ingvar3,Lalitha Rejani4,Kaswabuli Sylvia3,Andama Alfred34,Walter Nicholas D.5,Katamba Achilles26,Cattamanchi Adithya278,Worodria William4,Huang Laurence79,Yoon Christina78,Davis J. Lucian121011ORCID

Affiliation:

1. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA

2. Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda

3. Infectious Diseases Research Collaboration, Kampala, Uganda

4. Department of Medicine, Mulago Hospital, Makerere University, Kampala, Uganda

5. Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

6. Clinical Epidemiology Unit, Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda

7. Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA

8. Curry International Tuberculosis Center, University of California San Francisco, San Francisco, California, USA

9. Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, USA

10. Center for Methods in Implementation and Prevention Science, Yale School of Public Health, New Haven, Connecticut, USA

11. Pulmonary, Critical Care, and Sleep Medicine Section, Yale School of Medicine, New Haven, Connecticut, USA

Abstract

The objective of this prospective cross-sectional study, conducted at a national referral hospital in Kampala, Uganda, was to determine diagnostic performance of serum C-reactive protein (CRP) as a triage test for tuberculosis (TB) among HIV-seronegative inpatients. We calculated the sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values to determine the diagnostic performance of a CRP enzyme-linked immunosorbent assay (ELISA) (Eurolyser) in comparison to that of a reference standard of Mycobacterium tuberculosis culture on two sputum samples.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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