Induction of interferon synthesis in mice by fractions from Nocardia-Reference-Cited by-同舟云学术

Induction of interferon synthesis in mice by fractions from Nocardia

Published:1978-02 Issue:2 Volume:19 Page:353-356
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Barot-Ciorbaru R,Wietzerbin J,Petit J F,Chedid L,Falcoff E,Lederer E

Abstract

Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.19.2.353-356.1978

Reference15 articles.

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4. Bona C. C. Damais D. Juy and R. Ciorbaru. 1974. Immunological properties of water soluble extracts of Nocardiae. In Symposium International sur "les Immunostimulants Bacteriens " Pasteur Institute Paris 14-15 October 1974.

5. Human T-independent B-lymphocytes mitogen extracted from Nocardia opaca;Brochier J.;J. Immunol.,1976

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