RpoN-Dependent Direct Regulation of Quorum Sensing and the Type VI Secretion System in Pseudomonas aeruginosa PAO1-Reference-Cited by-同舟云学术

RpoN-Dependent Direct Regulation of Quorum Sensing and the Type VI Secretion System in Pseudomonas aeruginosa PAO1

Published:2018-08-15 Issue:16 Volume:200 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Shao Xiaolong¹,Zhang Xiaoning²,Zhang Yingchao¹,Zhu Miao²,Yang Pan¹,Yuan Jian¹,Xie Yingpeng³,Zhou Tianhong¹,Wang Wei¹,Chen Sheng⁴,Liang Haihua²,Deng Xin³

Affiliation:

1. Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China

2. Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China

3. Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong

4. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong

Abstract

As a global regulator, RpoN controls a wide range of biological pathways, including virulence in P. aeruginosa PAO1. This work shows that RpoN plays critical and global roles in the regulation of bacterial pathogenicity and fitness. ChIP-seq provided a useful database to characterize additional functions and targets of RpoN in the future. The functional characterization of RpoN-mediated regulation will improve the current understanding of the regulatory network of quorum sensing and virulence in P. aeruginosa and other bacteria.

Funder

National Natural Science Foundation of China

FHB | Health and Medical Research Fund

Natural Science Foundation of Tianjin City

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00205-18

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1. Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis