Separation of d -(+)-Nicotine from a Racemic Mixture by Stereospecific Degradation of the l -(−) Isomer with Pseudomonas putida

Author:

DeTraglia Michael C.1,Tometsko Andrew M.1

Affiliation:

1. Litron Laboratories, Ltd., Rochester, New York 14620

Abstract

Incubation of racemic mixtures of dl -(�)-nicotine with Pseudomonas putida resulted in a complete stereoselective degradation of the l -(−) isomer. Unnatural d -(+)-nicotine, which is of pharmacological interest for stereochemical studies of various nicotine-responsive systems, was not affected by the bacterium and was recovered by extraction.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference6 articles.

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2. Optically pure (+)nicotine from (-)nicotine and biological comparisons with (-)nicotine;Aceto M. D.;J. Med. Chem.,1979

3. Chemical nature of synaptic transmission in vertebrates;Krnjevic K.;Physiol. Rev.,1974

4. MacIntosh F. C. 1976. Acetylcholine p. 180-202. In G. J. Siegel R. W. Albers R. Katzman and B. W. Agranoff (ed.) Basic neurochemistry 2nd ed. Little Brown & Co. Boston.

5. Synthese des Nicotins;Pictet A.;Ber. Dent. Chem. Ges.,1904

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