Affiliation:
1. Litron Laboratories, Ltd., Rochester, New York 14620
Abstract
Incubation of racemic mixtures of
dl
-(�)-nicotine with
Pseudomonas putida
resulted in a complete stereoselective degradation of the
l
-(−) isomer. Unnatural
d
-(+)-nicotine, which is of pharmacological interest for stereochemical studies of various nicotine-responsive systems, was not affected by the bacterium and was recovered by extraction.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference6 articles.
1. Electrophysiological, behavioral and chemical evidence for a noncholinergic, stereospecific site for nicotine in rat brain;Abood L G;J. Neurosci. Res.,1978
2. Optically pure (+)nicotine from (-)nicotine and biological comparisons with (-)nicotine;Aceto M. D.;J. Med. Chem.,1979
3. Chemical nature of synaptic transmission in vertebrates;Krnjevic K.;Physiol. Rev.,1974
4. MacIntosh F. C. 1976. Acetylcholine p. 180-202. In G. J. Siegel R. W. Albers R. Katzman and B. W. Agranoff (ed.) Basic neurochemistry 2nd ed. Little Brown & Co. Boston.
5. Synthese des Nicotins;Pictet A.;Ber. Dent. Chem. Ges.,1904
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