TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation-Reference-Cited by-同舟云学术

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation

Published:2020-05-14 Issue:11 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Fan Xiaochen¹²,Waardenberg Ashley J.³,Demuth Madeleine¹,Osteil Pierre¹,Sun Jane Q. J.¹,Loebel David A. F.¹²,Graham Mark⁴,Tam Patrick P. L.¹²,Fossat Nicolas¹²

Affiliation:

1. Embryology Unit, Children’s Medical Research Institute, The University of Sydney, Sydney, Australia

2. The University of Sydney, School of Medical Sciences, Faculty of Medicine and Health, Sydney, Australia

3. Bioinformatics Group, The University of Sydney, Sydney, Australia

4. Synapse Proteomics Group, Children’s Medical Research Institute, The University of Sydney, Sydney, Australia

Abstract

The extensive array of basic helix-loop-helix (bHLH) transcription factors and their combinations as dimers underpin the diversity of molecular function required for cell type specification during embryogenesis. The bHLH factor TWIST1 plays pleiotropic roles during development. However, which combinations of TWIST1 dimers are involved and what impact each dimer imposes on the gene regulation network controlled by TWIST1 remain elusive. In this work, proteomic profiling of human TWIST1-expressing cell lines and transcriptome analysis of mouse cranial mesenchyme have revealed that TWIST1 homodimers and heterodimers with TCF3, TCF4, and TCF12 E-proteins are the predominant dimer combinations.

Funder

Children's Medical Research Institute

University of Sydney

Department of Health | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00663-19

Reference65 articles.