Affiliation:
1. Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105
Abstract
Because calcium was found to be antagonistic in vitro to the activity of colistin and polymyxin B on
Pseudomonas aeruginosa
, the effects of calcium and serum on gentamicin and carbenicillin were also examined. Serum was antagonistic to gentamicin in antibiotic tube dilution tests on five strains of
P. aeruginosa
. Serum was not antagonistic to carbenicillin in tube dilution tests. Physiologic concentrations of calcium antagonized the activity of gentamicin but not carbenicillin. The antagonism observed with gentamicin was less than that previously seen with colistin. The antagonistic effect of calcium and serum was removed by a chelating agent. Gentamicin and carbenicillin may be more active in vivo against
P. aeruginosa
than colistin or polymyxin B.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
9 articles.
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