Modification of Clearview Tuberculosis (TB) Enzyme-Linked Immunosorbent Assay for TB Patients Not Infected with HIV-Reference-Cited by-同舟云学术

Modification of Clearview Tuberculosis (TB) Enzyme-Linked Immunosorbent Assay for TB Patients Not Infected with HIV

Published:2013-09 Issue:9 Volume:20 Page:1479-1482
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Savolainen Laura¹,Kantele Anu¹²³,Sandboge Bettina¹,Sirén Marita¹,Valleala Heikki⁴,Tuompo Riitta⁴,Pusa Liana⁵,Erkinjuntti-Pekkanen Riitta⁶⁷,Knuuttila Aija⁸,Ku Cheng-Lung⁹,Chi Chih-Yu¹⁰,Vasankari Tuula¹¹,Tuuminen Tamara¹¹²

Affiliation:

1. Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland

2. Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

3. Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland

4. Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

5. Länsi-Uusimaa Hospital, Tammisaari, Finland

6. Unit of Medicine and Clinical Research, Pulmonary Division, University of Eastern Finland, Kuopio, Finland

7. Division of Respiratory Medicine, Department of Medicine, Kuopio University Hospital, Kuopio, Finland

8. Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland

9. Graduate Institute of Clinical Medical Science, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan

10. Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

11. Finnish Lung Health Association (FILHA), Helsinki, Finland

12. Eastern Finland Laboratory Centre Joint Authority Enterprise, Mikkeli, Finland

Abstract

ABSTRACT Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-fold allowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at University Hospital of Turku under registration no. 47/180/2009, Helsinki University Central Hospital under 149/2010, University Hospital of Kuopio under 105/2010, and China Medical University Hospital, Taichung, under DMR-99-IRB-075-2.)

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00375-13

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