Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model-Reference-Cited by-同舟云学术

Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Singh Kavindra V.¹²,Arias Cesar A.¹³⁴²⁵,Murray Barbara E.¹³²^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

2. UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), Houston, Texas, USA

3. Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, Houston, Texas, USA

4. Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia

5. Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA

Abstract

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van r , Amp r , DAP-nonsusceptible, linezolid-resistant, cfr (B) + Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00709-21

Reference27 articles.

1. Microbiology and Preclinical Review of Omadacycline

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