Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis

Author:

Yu Wei123,Yusuf Buhari123,Wang Shuai123,Tian Xirong124,Hameed H. M. Adnan12,Lu Zhili12,Chiwala Gift123ORCID,Alam Md Shah123,Cook Gregory M.56,Maslov Dmitry A.7ORCID,Zhong Nanshan28,Zhang Tianyu123ORCID

Affiliation:

1. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

2. Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

3. University of Chinese Academy of Sciences, Beijing, China

4. Institute of Physical Science and Information Technology, Anhui University, Hefei, China

5. Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

6. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand

7. Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

8. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Abstract

TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference31 articles.

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