Emergence of cfr -Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis-Reference-Cited by-同舟云学术

Emergence of cfr -Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis

Published:2016-03 Issue:3 Volume:60 Page:1878-1882
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Dios Caballero Juan¹²,Pastor María Dolores³,Vindel Ana⁴,Máiz Luis⁵,Yagüe Genoveva⁶,Salvador Carme⁶,Cobo Marta¹,Morosini María-Isabel¹²,del Campo Rosa¹²,Cantón Rafael¹²,

Affiliation:

1. Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain

2. Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain

3. Servicio de Neumología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain

4. Staphylococcus Reference Laboratory, Servicio de Bacteriología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

5. Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain

6. Servicio de Microbiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain

Abstract

ABSTRACT Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02067-15

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