Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo-Reference-Cited by-同舟云学术

Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo

Published:2020-07-16 Issue:15 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Yanqun¹,Sun Jing¹,Li Xiaobo²,Zhu Airu¹,Guan Wenda¹,Sun De-Qiang³,Gan Mian¹,Niu Xuefeng¹,Dai Jun²,Zhang Lu⁴,Zhang Zhaoyong¹,Shi Yongxia²,Huang Shuxiang²,Mok Chris Ka Pun¹⁵,Yang Zifeng¹,Wang Zhongfang¹,Tan Wenjie⁶,Li Yimin¹,Chen Ling¹⁷,Chen Rongchang⁸,Peiris Malik¹⁵,Zhong Nanshan¹,Zhao Jingxian¹,Huang Jicheng²,Zhao Jincun¹⁴

Affiliation:

1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

2. Technology Center, Guangzhou Custom, Guangzhou, China

3. State Key Laboratory of Respiratory Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, China

4. Institute of Infectious Disease, Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, China

5. Hong Kong HKU-Pasteur Research Pole, School of Public Health, HKU Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

6. Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

7. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

8. Shenzhen Institute of Respiratory Disease, First Affiliated Hospital of South University of Science and Technology of China (Shenzhen People’s Hospital), Shenzhen, China

Abstract

MERS-CoV is an important emerging pathogen and causes severe respiratory infection in humans. MERS-CoV strains from early epidemic clade A and contemporary epidemic clade B have not been phenotypically characterized to compare their abilities to infect cells and mice. In this study, we showed that a clade B virus ChinaGD01 strain caused more severe disease in mice, with delayed viral clearance, increased inflammatory cytokines, and decreased antiviral T cell responses, than the early clade A virus EMC/2012. Given the differences in pathogenicity of different clades of MERS-CoV, periodic assessment of currently circulating MERS-CoV is needed to monitor potential severity of zoonotic disease.

Funder

Guangdong Province Department of Science and Technology

National Key Research and Development of Science and Technology

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00861-20

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