Comparison of the activity of cefixime and activities of other oral antibiotics against adult clinical isolates of Moraxella (Branhamella) catarrhalis containing BRO-1 and BRO-2 and Haemophilus influenzae

Author:

Nash D R1,Flanagan C1,Steele L C1,Wallace R J1

Affiliation:

1. Department of Microbiology, University of Texas Health Center, Tyler 75710.

Abstract

MICs of 10 oral antibiotics were determined for 105 Moraxella catarrhalis and 96 Haemophilus influenzae isolates from adults. A two- to fourfold increase in MICs of oral cephalosporins was seen in the presence of BRO-1 but not with TEM-1 or BRO-2. The MICs of cefixime for 90% of strains of H. influenzae (0.125 microgram/ml) and M. catarrhalis (0.25 microgram/ml) were 8- to 64-fold lower than those of other oral cephalosporins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

1. Influence of growth medium and supplement on growth of Haemophilus influenzae and on antibacterial activity of several antibiotics;Bergeron M. G.;J. Clin. Microbiol.,1987

2. Tetracycline and erythromycin resistance among clinical isolates of Branhamella catarrhalis;Brown B. A.;Antimicrob. Agents Chemother.,1989

3. Flanagan C. W. L. C. Steele R. J. Wallace Jr. and D. R. Nash. 1988. Abstr. Annu. Meet. Am. Soc. Microbiol. 1988 A33 p. 6.

4. In vitro evaluation of cefixime (FK 027);Fuchs P. C.;Diagn. Microbiol. Infect. Dis,1986

5. Susceptibility of multiple resistant Haemophilus influenzae to newer antimicrobial agents;Jorgensen J. H.;Diagn. Microbiol. Infect. Dis.,1988

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