Affiliation:
1. Medical Research Division, American Cyanamid Co., Pearl River, New York 10965.
Abstract
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. but slightly less active than imipenem against staphylococci and streptococci. LJC10,627 showed stability to mouse dehydropeptidase I and was more effective in vivo than imipenem plus cilastatin against gram-negative bacterial infections and as effective against staphylococcal infections.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference11 articles.
1. The purification and properties of a particulate renal dipeptidase;Campbell J. B.;Biochim. Biophys. Acta,1966
2. Hikida M. M. Yoshida K. Nishiki Y. Furukawa K. Ubukata M. Konno and S. Mitshuhashi. 1989. Program Abstr. 29th Intersci. Conf. Antimicrob. Agents Chemother. abstr. 221.
3. Thienamycin: development of imipenem-cilastatin;Kahan F. M.;J. Antimicrob. Chemother.,1983
4. Imipenem: a new carbapenem antibiotic;Lipman B.;Med. Clin. North Am.,1988
5. Estimation of ED50 and its error by means of logarithmic-probit graph paper;Tainter;Proc. Soc. Exp. Biol. Med.,1944
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