Hygromycin B therapy of a murine coronaviral hepatitis-Reference-Cited by-同舟云学术

Hygromycin B therapy of a murine coronaviral hepatitis

Published:1991-10 Issue:10 Volume:35 Page:2125-2127
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Macintyre G¹,Curry B¹,Wong F¹,Anderson R¹

Affiliation:

1. Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.

Abstract

Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.10.2125

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