A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant-Reference-Cited by-同舟云学术

A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sevenich Marc¹²,van den Heuvel Joop³,Gering Ian¹,Mohrlüder Jeannine¹,Willbold Dieter¹⁴⁵^ORCID

Affiliation:

1. Institute of Biological Information Processing (IBI-7), Forschungszentrum Jülich, Jülich, Germany

2. Priavoid GmbH, Jülich, Germany

3. Helmholtz Centre for Infection Research, Braunschweig, Germany

4. Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

5. JuStruct, Forschungszentrum Jülich, Jülich, Germany

Abstract

The current SARS-CoV-2 pandemic is characterized by the high infectivity of SARS-CoV-2 and its derived variants of concern (VOCs). It has been widely assumed that the reason for its increased cell entry compared with SARS-CoV (2002) is due to alterations in the viral spike protein, where single amino acid residue substitutions can increase affinity for hACE2.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00685-22

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