Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition-Reference-Cited by-同舟云学术

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition

Published:2021-11-23 Issue:24 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Navaratnarajah Chanakha K.¹^ORCID,Pease David R.²,Halfmann Peter J.³,Taye Biruhalem¹,Barkhymer Alison¹,Howell Kyle G.⁴,Charlesworth Jon E.⁴,Christensen Trace A.⁴,Kawaoka Yoshihiro³⁵,Cattaneo Roberto¹^ORCID,Schneider Jay W.²^ORCID

Affiliation:

1. Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA

2. Discovery Engine/Program for Hypoplastic Left Heart Syndrome, Mayo Clinic, Rochester, Minnesota, USA

3. Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

4. Mayo Microscopy and Cell Analysis Core, Mayo Clinic, Rochester, Minnesota, USA

5. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Abstract

Cardiac complications frequently observed in COVID-19 patients are tentatively attributed to systemic inflammation and thrombosis, but viral replication has occasionally been confirmed in cardiac tissue autopsy materials. We developed an in vitro model of SARS-CoV-2 spread in myocardium using induced pluripotent stem cell-derived cardiomyocytes.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Japan Agency for Medical Research and Development

Mayo Clinic

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01368-21

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