Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8 + T-Cell Responses Which Can Be Defined to the Epitope Level-Reference-Cited by-同舟云学术

Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8 + T-Cell Responses Which Can Be Defined to the Epitope Level

Published:2008-11 Issue:11 Volume:15 Page:1745-1748
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Erickson A. L.¹²³⁴,Willberg C. B.¹²³⁴,McMahan V.¹²³⁴,Liu A.¹²³⁴,Buchbinder S. P.¹²³⁴,Grohskopf L. A.¹²³⁴,Grant R. M.¹²³⁴,Nixon D. F.¹²³⁴

Affiliation:

1. Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110

2. Gladstone Institute of Virology and Immunology, UCSF, San Francisco, California 94158

3. Division of VCF and Epidemiology, Department of Medicine, UCSF, San Francisco, California 94143

4. Epidemiology Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

Abstract

ABSTRACT We measured CD8 + T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00247-08

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