1-Palmitoyl-2-Linoleoyl-3-Acetyl- rac -Glycerol Attenuates Streptozotocin-Induced Pancreatic Beta Cell Damage by Promoting Glucose Transporter 2 Endocytosis-Reference-Cited by-同舟云学术

1-Palmitoyl-2-Linoleoyl-3-Acetyl- rac -Glycerol Attenuates Streptozotocin-Induced Pancreatic Beta Cell Damage by Promoting Glucose Transporter 2 Endocytosis

Published:2019-11 Issue:21 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kim Jimin¹²,Kim Joo Heon³,Sohn Ki-Young⁴,Yoon Sun Young⁴,Kim Jae Wha¹²

Affiliation:

1. Cell Factory Research Center, Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

2. Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon, Republic of Korea

3. Department of Pathology, EulJi University School of Medicine, Daejeon, Republic of Korea

4. Division of Global New Drug Development, Enzychem Lifesciences, Jecheon, Republic of Korea

Abstract

Streptozotocin (STZ) is widely used to induce diabetic rodent models. It is specifically toxic to pancreatic beta cells and causes severe destruction and dysfunction. We investigated the effect of 1-palmitoyl-2-linoleoyl-3-acetyl- rac -glycerol (PLAG) on an STZ-induced diabetic mouse model. PLAG attenuated the glucose increase and maintained serum insulin at levels similar to those seen with control mice.

Funder

University of Science and Technology

Enzychem Lifesciences

Korea Research Institute of Bioscience and Biotechnology

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00157-19

Reference44 articles.

1. Mode of Action of Streptozotocin