Histoplasma capsulatum Complement Fixation and Immunodiffusion Assay Sensitivity in Culture-Confirmed Cases of Histoplasmosis: a 10-Year Retrospective Review (2011 to 2020)

Author:

Fida Madiha1,Misra Anisha2,Harring Julie A.2,Kubbara Aahd3,Theel Elitza S.2ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

2. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

3. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

Abstract

The detection of antibodies against Histoplasma capsulatum remains a frequently relied-on approach to diagnose histoplasmosis. We retrospectively assessed the performances of complement fixation (CF) and immunodiffusion (ID) assays for anti- Histoplasma antibody detection in patients with culture-confirmed histoplasmosis at Mayo Clinic (Rochester, MN) over a 10-year period (2011 to 2020).

Funder

Mayo Clinic

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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