pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies-Reference-Cited by-同舟云学术

pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

Published:2010-10 Issue:10 Volume:48 Page:3797-3799
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Witkowski Benoit¹²,Iriart Xavier¹³,Soh Patrice Njomnang¹²,Menard Sandie¹³,Alvarez Muriel⁴,Naneix-Laroche Veronique⁴,Marchou Bruno⁴,Magnaval Jean-François³,Benoit-Vical Françoise¹²,Berry Antoine¹³

Affiliation:

1. Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, and Faculté de Médecine de Rangueil, Université de Toulouse III, Toulouse, France

2. CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Université de Toulouse III, Toulouse, France

3. UMR3 MD-UM-UPS, Université Paul Sabatier Toulouse III, Toulouse, France

4. Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France

Abstract

ABSTRACT We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, which is also known to alter the susceptibility to artemisinin combination therapy (ACT).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01057-10

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