Low Frequency of Intermittent HIV-1 Semen Excretion in Patients Treated with Darunavir-Ritonavir at 600/100 Milligrams Twice a Day plus Two Nucleoside Reverse Transcriptase Inhibitors or Monotherapy-Reference-Cited by-同舟云学术

Low Frequency of Intermittent HIV-1 Semen Excretion in Patients Treated with Darunavir-Ritonavir at 600/100 Milligrams Twice a Day plus Two Nucleoside Reverse Transcriptase Inhibitors or Monotherapy

Published:2010-11 Issue:11 Volume:54 Page:4910-4913
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lambert-Niclot Sidonie¹,Peytavin Gilles²,Duvivier Claudine³⁴,Poirot Catherine⁵,Algarte-Genin Michèle⁶,Pakianather Sophie⁶,Meynard Jean-Luc⁷,Valantin Marc-Antoine⁸,Molina Jean-Michel⁹,Flandre Philippe¹⁶,Katlama Christine⁸,Calvez Vincent¹,Marcelin Anne-Geneviève¹

Affiliation:

1. Virology Department, AP-HP, Pitié-Salpêtrière Hospital, UPMC Université Paris 06, and INSERM U943, Paris, France

2. Clinical Pharmacy Department, AP-HP, Bichat Claude-Bernard Hospital, and EA 449 Paris 7 University, Paris, France

3. Centre d'Infectiologie Necker-Pasteur, AP-HP, Hôpital Necker-Enfants malades, Université René Descartes Paris 4, Paris, France

4. Institut Pasteur, Centre Médical de l'Institut Pasteur, Paris, France

5. UF biologie de la Reproduction, AP-HP, Pitié-Salpêtrière Hospital, UPMC Université Paris 06, Paris, France

6. INSERM UMR-S 943 and UPMC Université Paris 06, Paris, France

7. Infectious Diseases Department, AP-HP, Saint Antoine Hospital, Paris, France

8. Infectious Diseases Department, AP-HP, Pitié-Salpêtrière Hospital, and INSERM U943, Paris, France

9. Infectious Diseases Department, AP-HP, Saint Louis Hospital, Paris, France

Abstract

ABSTRACT HIV-1 RNA level and darunavir concentration in the genital tract were measured in 45 men receiving darunavir-ritonavir mono- or tritherapy. At week 48, a low frequency (3/45) of HIV-1 RNA shedding was observed in patients (1 on monotherapy and 2 on triple therapy), although they had undetectable HIV-1 RNA in plasma. The median darunavir seminal plasma concentration was close to the blood plasma free fraction, demonstrating a good penetration of darunavir into the male genital tract.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00725-10

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