Nonsegmented Negative-Sense RNA Viruses Utilize N 6 -Methyladenosine (m 6 A) as a Common Strategy To Evade Host Innate Immunity

Author:

Lu Mijia1,Xue Miaoge1,Wang Hai-Tao23,Kairis Elizabeth L.1,Ahmad Sadeem23,Wei Jiangbo456,Zhang Zijie456,Liu Qinzhe456,Zhang Yuexiu1,Gao Youling1,Garcin Dominique7ORCID,Peeples Mark E.89ORCID,Sharma Amit110,Hur Sun23,He Chuan45611,Li Jianrong1ORCID

Affiliation:

1. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

3. Program in Cellular and Molecular Medicine, Boston Children's Hospital, Massachusetts, USA

4. Department of Chemistry, The University of Chicago, Chicago, Illinois, USA

5. Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA

6. Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA

7. Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, Geneva, Switzerland

8. Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

9. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

10. Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA

11. Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA

Abstract

The nonsegmented negative-sense (NNS) RNA viruses share many common replication and gene expression strategies. There are no vaccines or antiviral drugs for many of these viruses.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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