Abstract
In surface culture of Penicillium simplicissimum, verruculogen was shown to be biosynthesized from the intact carbon skeletons of tryptophan and proline, isoprenoid derivatives of mevalonic acid, and a methyl group donated by methionine. Selected radiolabeled precursors (1 mCi) pulse-fed at the optimum stage of fermentation yielded verruculogen (specific activity, 5.89 X 10(2) microCi mmol-1) labeled in the prolyl and isoprenyl regions of the molecule and suitable for metabolic studies.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference12 articles.
1. The mycotoxin verruculogen: a 6-0-methylindole;Cole R. J.;J. Agric. Food Chem.,1973
2. Tremorgenic toxin from Penicillium verruculosum;Cole R. J.;Appl. Microbiol.,1972
3. Tremorgenic forage and ryegrass staggers;Day J. B.;Vet. Rec.,1980
4. Day J. B. and P. G. Mantle. 1981. Analysis and fermentation production of the tremorgenic mycotoxin verruculogen. In Mycotoxins and phycotoxins in human and animal health. Pathotox Publishers Inc. Park Forest South Ill.
5. Production of verruculogen by Penicillium estinogenum in stirred fermenters;Day J. B.;J. Gen. Microbiol.,1980
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献