Affiliation:
1. Mycology Division, Center for Disease Control, Atlanta, Georgia 30333
Abstract
Sera from 71 patients with culturally proven nocardiosis were tested for precipitins against a pool of
Nocardia asteroides
and
N. brasiliensis
culture filtrates and against antigens from the supernatant of homogenized
N. asteroides
cells. A human nocardiosis case serum was used as a reference. Sera from 56 of the 71 cases were reactive with either the culture filtrate antigen, the homogenate antigen, or both antigens, resulting in an overall sensitivity of 79%. Sera from 35 of the patients (49%) were positive with the homogenate antigens, and 28 (39%) showed bands of identity with the reference serum. Sera from 50 nocardiosis cases (70%) were positive with the pooled culture filtrate antigens, and 29 (41%) produced bands of identity with the reference serum. Of 89 sera from patients with various systemic mycotic diseases, tuberculosis, or actinomycosis, 24 (27%) were positive with the nocardial homogenate antigens and 4 (4.5%) showed precipitin bands of identity. Thirty-five of the 89 sera (42%) were positive with the nocardial culture filtrate antigens, and 6 (6.7%) showed bands of identity. The majority of sera demonstrating false-positive reactions were from tuberculosis and actinomycosis cases. One of seven sera from well individuals produced a precipitin band with the culture filtrate antigen, but this was not a band of identity with reference serum. These antigens did not distinguish antibodies from patients with
N. asteroides, N. brasiliensis,
or
N. cavia
infections.
Publisher
American Society for Microbiology
Reference10 articles.
1. Nocardial infections in the United States, 1972-1974;Beaman B. L;J. Infect. Dis.,1976
2. Precipitin and skin tests in the diagnosis of mycetoma due to Nocardia brasiliensis;Bojalil L F;Proc. Soc. Exp. Biol. Med.,1963
3. Nocardiosis: A review of 25 cases occurmng during 24 months;Frazier A. R.;Mayo Clin. Proc.,1975
4. Nocardia infections in a general hospital;Goodman J. S.;Ann. N. Y. Acad. Sci.,1970
5. Serological reactions to Nocardia antigens;Humphreys D. W.;Am. J. Med. Sci.,1975
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