A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens-Reference-Cited by-同舟云学术

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens

Published:1992-08 Issue:15 Volume:174 Page:5141-5144
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Hara O¹,Hutchinson C R¹

Affiliation:

1. Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

Abstract

The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.174.15.5141-5144.1992

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