Characterization of the Biosynthetic Gene Cluster and Shunt Products Yields Insights into the Biosynthesis of Balmoralmycin

Author:

Ma Guang-Lei1,Xin Lingyi1,Liao Yanghui1,Chong Zhi-Soon1,Candra Hartono1,Pang Li Mei1,Lee Sean Qiu En1,Gakuubi Martin Muthee12,Ng Siew Bee2,Liang Zhao-Xun1ORCID

Affiliation:

1. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

2. Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore

Abstract

Angucyclines are structurally diverse aromatic polyketides that have attracted considerable attention due to their potent bioactivity and intriguing biosynthetic origin. Balmoralmycin is a representative of a small family of angucyclines with unique structural features and an unknown biosynthetic origin.

Funder

Ministry of Education - Singapore

National Research Foundation Singapore

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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