Herpes Simplex Virus 2 in Autonomic Ganglia: Evidence for Spontaneous Reactivation-Reference-Cited by-同舟云学术

Herpes Simplex Virus 2 in Autonomic Ganglia: Evidence for Spontaneous Reactivation

Published:2019-06 Issue:11 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pieknik Julianna R.¹²,Bertke Andrea S.³^ORCID,Krause Philip R.²^ORCID

Affiliation:

1. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA

3. Department of Population Health Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

Abstract

HSV-2 is a ubiquitous important human pathogen that causes recurrent infections for the life of its host. We hypothesized that the autonomic ganglia have important roles in viral reactivation, and this study sought to determine whether this is correct in the clinically relevant guinea pig vaginal infection model. Our findings indicate that sympathetic ganglia are sources of reactivating virus, helping explain how the virus causes lifelong recurrent disease.

Funder

HHS | U.S. Food and Drug Administration

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00227-19

Reference35 articles.

1. Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012

2. Seroprevalence of Herpes Simplex Virus Types 1 and 2--United States, 1999-2010