Affiliation:
1. Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia
Abstract
The mosquito
Aedes aegypti
transmits a number of arthropod-borne viruses (arboviruses), such as dengue virus and Zika virus. Mosquitoes also harbor insect-specific viruses that may affect replication of pathogenic arboviruses in their body. Currently, however, there are only a few insect-specific viruses described from
A. aegypti
in the literature. Here, we characterize a novel negative-strand virus, AeAV. Meta-analysis of
A. aegypti
samples showed that it is present in
A. aegypti
mosquitoes worldwide and is vertically transmitted.
Wolbachia
-transinfected mosquitoes are currently being used in biocontrol, as they effectively block transmission of several positive-sense RNA viruses in mosquitoes. Our results demonstrate that
Wolbachia
enhances the replication of AeAV and modestly reduces dengue virus replication in a cell line model. This study expands our understanding of the virome in
A. aegypti
as well as providing insight into the complexity of the
Wolbachia
virus restriction phenotype.
Funder
Department of Education and Training | Australian Research Council
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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