Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bala Veenu¹²,Chhonker Yashpal S.¹,Alshehri Abdullah¹,Edi Constant³,Bjerum Catherine M.⁴,Koudou Benjamin G.³⁵⁶,King Christopher L.⁴⁷,Murry Daryl J.¹⁸^ORCID

Affiliation:

1. Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, Nebraska, USA

2. Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

3. Centre Suisse de Recherche Scientifique en Côte d’Ivoire, Abidjan, Côte d’Ivoire

4. Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

5. Université Nangui Abrogoua, Abidjan, Côte d’Ivoire

6. Liverpool School of Tropical Medicine, Liverpool, United Kingdom

7. Veterans Affairs Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA

8. Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

Abstract

Diethylcarbamazine (DEC) is a drug of choice to treat lymphatic filariasis (LF) either used alone or in combination as mass drug administration (MDA) preventive strategies. The objective of this study was to develop a population pharmacokinetics (PK) model for DEC in subjects infected with lymphatic filariasis (LF) compared to healthy individuals, and to evaluate the effect of covariates on the volume of distribution ( V / F ) and oral clearance (CL/ F ) of DEC. This was an open-label cohort study of treatment-naive Wuchereria bancrofti -infected ( n = 32) and uninfected ( n = 24) adults residing in the Agboville District of Côte d’Ivoire.

Funder

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00317-21

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