In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis-Reference-Cited by-同舟云学术

In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kim Seong Eun¹,Kim Hee Kyung¹²,Choi Su-Mi¹,Yu Yohan¹,Kim Uh Jin¹,Darboe Kalifa Sanneh¹²,Kang Seung-Ji¹,Park Kyung-Hwa¹,Kang Gaeun³,Kim Young Ran⁴,Rhee Joon Haeng⁵⁶,Jung Sook-In¹,Jang Hee-Chang¹

Affiliation:

1. Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea

2. Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Republic of Korea

3. Department of Clinical Pharmacology, Chonnam National University Hospital, Gwangju, Republic of Korea

4. College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea

5. Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea

6. Clinical R&D Center, Chonnam National University Medical School, Gwangju, Republic of Korea

Abstract

The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.

Funder

Chonnam National University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00310-19

Reference27 articles.

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2. The Epidemiology of Vibrio Infections in Florida, 1981-1993

3. In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus